Optical phase coherent timing of the Crab nebula pulsar with Iqueye at the ESO New Technology Telescope

The Crab nebula pulsar was observed in 2009 January and December with a novel very fast optical photon counter, Iqueye, mounted at the ESO 3.5 m New Technology Telescope. Thanks to the exquisite quality of the Iqueye data, we computed accurate phase coherent timing solutions for the two observing runs and over the entire year 2009. Our statistical uncertainty on the determination of the phase of the main pulse and the rotational period of the pulsar for short (a few days) time intervals are $\approx 1 \, \mu$s and ~0.5 ps, respectively. Comparison with the Jodrell Bank radio ephemerides shows that the optical pulse leads the radio one by ~240 $\mu$s in January and ~160 $\mu$s in December, in agreement with a number of other measurements performed after 1996. A third-order polynomial fit adequately describes the spin-down for the 2009 January plus December optical observations. The phase noise is consistent with being Gaussian distributed with a dispersion $\sigma$ of $\approx 15 \, \mu$s in most observations, in agreement with theoretical expectations for photon noise-induced phase variability.Comment: 10 pages, 5 figures. Accepted for publication in Monthly Notices of the Royal Astronomical Societ

Three-dimensional numerical modeling of tsunami-related internal gravity waves in the Hawaiian atmosphere

The tremendous tsunami following the 2011 Tohoku Earthquake produced internal gravity waves (IGWs) in the neutral atmosphere and large disturbances in the. overlying ionospheric plasma while propagating through the Pacific ocean. To corroborate the tsunamigenic hypothesis of these perturbations, we use a 3D numerical modeling of the ocean-atmosphere coupling, to reproduce the tsunami signature observed in the airglow by the imager located in Hawaii and clearly showing the shape of the modeled IGW. The agreement between data and synthetics not only supports the interpretation of the tsunami-related-IGW behavior, but strongly shows that atmospheric and ionospheric remote sensing can provide new tools for oceanic monitoring and tsunami detection

Collimator design for a clinical brain SPECT/MRI insert

This project's goal is to design a SPECT insert for a clinical MRI system for simultaneous brain SPECT/MR imaging. We assume the stationary SPECT insert will consist of two rings of ∼5x5-cm SiPM-based detectors insensitive to magnetic fields, with 0.8-mm intrinsic resolution. The maximum diameter is 44.5 cm, the minimum diameter is 33 cm to accommodate the patient and MRI receive/transmit coil, and the FOV has a 20 cm diameter. We have compared eight collimator designs: single-, 2x2-, 3x3- and 5+2½- pinhole, and single-, 2-, 3- and 1+2½-slit slit-slat, where ½-pinholes/slits are shared between two detectors. Analytical geometric efficiency was calculated for an activity distribution corresponding to a human brain and a target resolution of 10 mm FWHM at the centre of the FOV. Noise-free data were simulated with and without depth-of-interaction (DOI) information, and reconstructed for uniform, Defrise, Derenzo, and Zubal brain phantoms. For DOI it is assumed that the crystal's first and second half can be differentiated. Comparing the multi-pinhole and multi-slit slit-slat collimators, the former gives better reconstructed uniformity and trans-axial resolution, while the latter gives better axial resolution. Although the 2x2-pinhole and 2-slit designs give the highest sensitivities, they result in a sub-optimal utilization of the detector FOV. The best options are therefore the 5+2½-pinhole and the 1+2½-slit systems, with sensitivities of 4.9*10–4 and 4.0*10–4, respectively. The brain phantom reconstructions with multi-pinhole collimator are superior as compared to slit-slat, especially in terms of symmetry and realistic activity distribution. DOI information reduces artefacts and improves uniformity in geometric phantoms, although the difference is small for the brain phantom. These results favour a multi-pinhole configuration

Aqueye optical observations of the Crab Nebula pulsar

We observed the Crab pulsar in October 2008 at the Copernico Telescope in Asiago - Cima Ekar with the optical photon counter Aqueye (the Asiago Quantum Eye) which has the best temporal resolution and accuracy ever achieved in the optical domain (hundreds of picoseconds). Our goal was to perform a detailed analysis of the optical period and phase drift of the main peak of the Crab pulsar and compare it with the Jodrell Bank ephemerides. We determined the position of the main peak using the steepest zero of the cross-correlation function between the pulsar signal and an accurate optical template. The pulsar rotational period and period derivative have been measured with great accuracy using observations covering only a 2 day time interval. The error on the period is 1.7 ps, limited only by the statistical uncertainty. Both the rotational frequency and its first derivative are in agreement with those from the Jodrell Bank radio ephemerides archive. We also found evidence of the optical peak leading the radio one by ~230 microseconds. The distribution of phase-residuals of the whole dataset is slightly wider than that of a synthetic signal generated as a sequence of pulses distributed in time with the probability proportional to the pulse shape, such as the average count rate and background level are those of the Crab pulsar observed with Aqueye. The counting statistics and quality of the data allowed us to determine the pulsar period and period derivative with great accuracy in 2 days only. The time of arrival of the optical peak of the Crab pulsar leads the radio one in agreement with what recently reported in the literature. The distribution of the phase residuals can be approximated with a Gaussian and is consistent with being completely caused by photon noise (for the best data sets).Comment: 7 pages, 7 figures. Accepted for publication in Astronomy and Astrophysic

Crizotinib plus radiotherapy in brain oligoprogressive NSCLC ROS1 rearranged and PD-L1 strong

ROS1+ patients represent a unique molecular subset of non-small cell lung cancer (NSCLC). Early phase clinical trials have shown a high response rate to crizotinib in these patients. We describe a case of an 18 years old woman, never smoker, with NSCLC ROS1+ and miliary brain metastases treated with crizotinib and radiotherapy. From October 2014 to June 2015 the Patient was treated with crizotinib. The first intracranial time to progression (IT-TTP) occurred after 7 months; the patient underwent stereotactic radiosurgery (SRS) and continued TKI treatment. The second IT-TTP appeared after 16 months. A continued response in the chest was observed for all the 23 months of crizotinib treatment. At the progression, we assessed programmed death ligand 1 (PD-L1) expression by immunohistochemistry, that resulted highly expressed. Our report indicates that the integration of crizotinib with local treatments should be considered in ROS1 NSCLC patients experiencing oligometastatic progression. Moreover, this case is an example of PD-L1 strong in oncogene addicted patients

Low levels of urinary psa better identify prostate cancer patients

SIMPLE SUMMARY: Elevated PSA levels in blood tests are the gold standard for early prostate cancer detection, but its lack of specificity limits its clinical use as a mass screening test. The paradox is that it has long been known that advanced prostate cancers can lose PSA expression. We have observed that in the presence of tumors, the prostate produces and secretes less PSA than in healthy or benign conditions. Therefore, the PSA evaluation in urine provided more accurate information on the presence of prostate tumors than the blood test, representing a new method for the screening of prostate cancer. ABSTRACT: Serum prostatic specific antigen (PSA) has proven to have limited accuracy in early diagnosis and in making clinical decisions about different therapies for prostate cancer (PCa). This is partially due to the fact that an increase in PSA in the blood is due to the compromised architecture of the prostate, which is only observed in advanced cancer. On the contrary, PSA observed in the urine (uPSA) reflects the quantity produced by the prostate, and therefore can give more information about the presence of disease. We enrolled 574 men scheduled for prostate biopsy at the urology clinic, and levels of uPSA were evaluated. uPSA levels resulted lower among subjects with PCa when compared to patients with negative biopsies. An indirect correlation was observed between uPSA amount and the stage of disease. Loss of expression of PSA appears as a characteristic of prostate cancer development and its evaluation in urine represents an interesting approach for the early detection of the disease and the stratification of patients

Unexpected long survival of brain oligometastatic non-small cell lung cancer (NSCLC) treated with multimodal treatment: A single-center experience and review of the literature

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Fifty percent of the cases are metastatic at diagnosis and about 20% develop brain metastasis. The brain involvement represents a negative prognostic factor. However, some patients could benefit from locoregional treatments of metastatic foci and experience an unexpected long survival or healing. In the previous years some classifications were proposed to identify patients' prognostic category, according to stage of the primary tumor, the timing of metastases occurrence (synchronous or metachronous) and the number of metastatic sites. Several data show a benefit in patients receiving resection of both the primary tumor and brain metastases. Whole brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) are the selected options in most cases. Overall, literature data showed highly variable outcome, with an overall survival (OS) ranging from 5.9 to 68 months. No data from randomized and homogeneous trials are currently available. Therefore, a growing interest in this field is observed. Different trials investigating the effectiveness of local treatments and studies analyzing biological mechanisms are ongoing. In this report we analyze literature data and we explore the current field of study. Furthermore, we show a single institutional experience of multimodal management of stage IV NSCLC with brain metastases, experiencing an unexpected long survival. We conclude that a better knowledge of this subpopulation of patients and new studies in this field can lead to distinguish the patients who can benefit from local treatment from those with poor prognosis

Modelling of the Total Electronic Content and magnetic field anomalies generated by the 2011 Tohoku-oki tsunami and associated acoustic-gravity waves,

International audienceIn this work, numerical simulations of the atmospheric and ionospheric anomalies are performed for the Tohoku-Oki tsunami (2011 March 11). The Tsunami-Atmosphere-Ionosphere (TAI) coupling mechanism via acoustic gravity waves (AGWs) is explored theoretically using the TAI-coupled model. For the modelled tsunami wave as an input, the coupled model simulates the wind, density and temperature disturbances or anomalies in the atmosphere and electron density/magnetic anomalies in the F region of the ionosphere. Also presented are the GPS-total electron content (TEC) and ground-based magnetometer measurements during the first hour of tsunami and good agreements are found between modelled and observed anomalies. At first, within 6 min from the tsunami origin, the simulated wind anomaly at 250 km altitude and TEC anomaly appear as the dipole-shaped disturbances around the epicentre, then as the concentric circular wave fronts radially moving away from the epicentre with the horizontal velocity ∼800 m s−1 after 12 min followed by the slow moving (horizontal velocity ∼250 m s−1) wave disturbance after 30 min. The detailed vertical-horizontal propagation characteristics suggest that the anomalies appear before and after 30 min are associated with the acoustic and gravity waves, respectively. Similar propagation characteristics are found from the GPS-TEC and magnetic measurements presented here and also reported from recent studies. The modelled magnetic anomaly in the F region ionosphere is found to have similar temporal variations with respect to the epicentre distance as that of the magnetic anomaly registered from the ground-based magnetometers. The high-frequency component ∼10 min of the simulated wind, TEC and magnetic anomalies in the F region develops within 6-7 min after the initiation of the tsunami, suggesting the importance of monitoring the high-frequency atmospheric/ionospheric anomalies for the early warning. These anomalies are found to maximize across the epicentre in the direction opposite to the tsunami propagation suggesting that the large atmospheric/ionospheric disturbances are excited in the region where tsunami does not travel

Psychological distress and quality of life in lung cancer: The role of health-related stigma, illness appraisals and social constraints

Objective: Health-related stigma is associated with negative psychological and quality of life outcomes in lung cancer patients. This study describes the impact of stigma on lung cancer patients\u27 psychological distress and quality of life and explores the role of social constraints and illness appraisal as mediators of effect. Methods: A self-administered cross-sectional survey examined psychological distress and quality of life in 151 people (59% response rate) diagnosed with lung cancer from Queensland and New South Wales. Health-related stigma, social constraints and illness appraisals were assessed as predictors of adjustment outcomes. Results: Forty-nine percent of patients reported elevated anxiety; 41% were depressed; and 51% had high global distress. Health-related stigma was significantly related to global psychological distress and quality of life with greater stigma and shame related to poorer outcomes. These effects were mediated by illness appraisals and social constraints. Conclusions: Health-related stigma appears to contribute to poorer adjustment by constraining interpersonal discussions about cancer and heightening feelings of threat. There is a need for the development and evaluation of interventions to ameliorate the negative effects of health-related stigma among lung cancer patients